Product Description: Relacorilant is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively. Relacorilant has the potential for Cushing’s syndrome treatment.
Applications: Metabolism-sugar/lipid metabolism
Formula: C27H22F4N6O3S
References: [1]Hunt HJ, et al. Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist. J Med Chem. 2017 Apr 27;60(8):3405-3421.
CAS Number: 1496510-51-0
Molecular Weight: 586.56
Compound Purity: 99.12
Research Area: Cardiovascular Disease; Endocrinology
Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Glucocorticoid Receptor
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