Formulation: A crystalline solid
Formal Name: 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile
Purity: ≥95%
Formula Markup: C15H14N4S
Formula Weight: 282,4
Shelf life (days): 1460
CAS Number: 949912-58-7
Notes: Progeria is a genetic disorder that results in the appearance of premature aging. Genetically, progeria is characterized by a mutation in lamin A, which results in misshapen cell nuclei and DNA damage. Remodelin is a 2-thiazolylhydrazone derivative that, at 10 µM, improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria.{26026} Remodelin is an inhibitor of N-acetyltransferase 10 (NAT10), which acetylates both histones and microtubules.{26026} Mutation of NAT10 mimics the effects of remodelin on nuclear morphology, suggesting that these effects of remodelin require NAT10.{26026} Remodelin also has cytotoxic effects against some species of the fungus Candida.{25935}
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