Formulation: A crystalline solid
Formal Name: α-methyl-tricyclo[3.3.1.13,7]decane-1-methanamine, monohydrochloride
Purity: ≥98%
Formula Markup: C12H21N • HCl
Formula Weight: 215,8
Shelf life (days): 1460
CAS Number: 1501-84-4
Notes: Rimantadine is a derivative of amantadine (Item No. 21364) with antiviral activity.{22179} It inhibits recombinant influenza A matrix protein 2 (M2) expressed in X. laevis oocytes (IC50 = 10.8 µM) and recombinant hepatitis C virus (HCV) p7 protein expressed in HEK293 cells (IC50s = 0.7, 24, 1.6, and 3.0 nM for HCV genotypes 1a, 2a, 3a, and 4a, respectively).{43207,43208} Rimantadine inhibits cytotoxicity induced by the influenza A strains A/PR/8/34 (H1N1) and A/HK/7/87 (H3N2), but not the influenza B strain B/HK/72, in MDCK cells (EC50s = 18, 0.62, and >500 µM, respectively).{42218} It increases the survival rate of mice infected with the influenza A strain A2/Jap/305 from 20 to 90% when administered at a dose of 24 mg/kg two hours post-infection, with the survival rate decreasing when rimantadine is administered at longer timepoints following infection.{43209} It also has trypanocidal activity against bloodstream forms of T. brucei in vitro (IC50 = 1.26 µg/ml).{43210} Formulations containing rimantadine have been used in the prophylaxis and treatment of influenza A.
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