RO9021, CAS 1446790-62-0

Formulation: A solid

Formal Name: 6-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[(5,6-dimethyl-2-pyridinyl)amino]-3-pyridazinecarboxamide

Purity: ≥90%

Formula Markup: C18H25N7O

Formula Weight: 355,4

Shelf life (days): 1460

CAS Number: 1446790-62-0

Notes: RO9021 is an inhibitor of spleen tyrosine kinase (Syk; IC50 = 5.6 nM).{64841} It is selective for Syk over a panel of 392 other kinases at 1 µM. RO9021 also inhibits M. tuberculosis serine/threonine protein kinase G (PknG; IC50 = 4.4 µM).{64842} It inhibits the proliferation of, and induces apoptosis in, primary acute myeloid leukemia (AML) cells when used at a concentration of 5 µM.{64843} RO0921 prevents RANKL- and M-CSF-induced osteoclastogenesis in isolated mouse bone marrow-derived macrophages (BMDMs; IC50 = 145 nM).{64841} It reduces disease severity in a mouse model of collagen-induced arthritis when administered at doses of 5 or 45 mg/kg.

• Artikelnummer: CAY37543-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37543-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe