ROCK1, GST-tag Recombinant

ROCK1, GST-tag Recombinant
Artikelnummer
BPS40085
Verpackungseinheit
10 µg
Hersteller
BPS Bioscience

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Encompassing Amino Acids: 17-535

Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. 

Background: ROCK1 is a ubiquitously expressed serine/threonine kinase that is a downstream target of the small GTPase RhoA. ROCK1 is involved in diverse cellular functions, including smooth muscle contraction, actin cytoskeleton organization, cell adhesion and motility, and gene expression (1). ROCK1 contributes to the development of cardiac fibrosis and induction of fibrogenic cytokines in cardiomyocytes in response to pathological stimuli. ROCK1 knockout mice exhibit reduced perivascular and interstitial fibrosis which is associated with reduced expression of a variety of extracellular matrix (ECM) proteins and fibrogenic cytokines (2).

Description: Recombinant human ROCK1 (a.a. 17-535) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST-tag. The gene accession number is NM_005406.

Format: Aqueous buffer solution

Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

Genbank: NM_005406

Host Cell Line: Sf9 cells

Purity: ≥90%

Storage Stability: At least 6 months at -80°C.

Tags: N-terminal GST-tag

Uniprot: Q13464

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: 1. Zhao, Y M. et al. Dev Biol. 2004 Nov 1,275(1):183-91.
2. Zhang, C. et al. FASEB J. 2006 May,20(7):916-25.
Mehr Informationen
Artikelnummer BPS40085
Hersteller BPS Bioscience
Hersteller Artikelnummer 40085
Green Labware Nein
Verpackungseinheit 10 µg
Mengeneinheit STK
Wirt Insect
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