S100A8 Polyclonal Antibody, Rabbit

Abbreviation: S100A8

Target Synonym: p; Ca; MR; p8; B8A; CFA; B8Ag; CFAg; CP-1; Caga; MRP8; 60B8A; CP-10; 60B8Ag; AI323541

Conjugation: Unconjugated

UNIProt ID: P27005

Background: S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9 which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of mouse S100A8

Dilution: WB 1:500-1:2000,IHC 1:50-1:200

• Artikelnummer: ELSE-AB-93263-200
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-E-AB-93263-200
• Green Labware: Nein
• Verpackungseinheit: 200 µl
• Mengeneinheit: STK
• Reaktivität: Mouse (Murine), Rat (Rattus)
• Klonalität: Polyclonal
• Methode: Western Blotting, Immunohistochemistry
• Isotyp: IgG
• Wirt: Rabbit