S1P1 Polyclonal Antibody (protein A-purified)

Formulation: 500 µl of protein-A purified polyclonal antibody

Immunogen: Peptide from the internal region of human S1P1

Shelf life (days): 1095

Notes: Sphingosine-1-phosphate (S1P) exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8.{11895,12477} S1P1 primarily couples with pertussis toxin-sensitive Gi/o proteins to mediate S1P-induced cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.{11895,12477,10628} Expression of S1P1 is abundant in embryological vasculature and is ubiquitously expressed in adult cells, suggesting diverse physiological functions of this receptor.{12477} The human and mouse S1P1 receptors have 382 amino acids with an estimated molecular weight of 43 kDa. Glycosylation at the N-terminal extracellular domain may cause the protein to migrate at a higher position in SDS-PAGE.{12476} Cayman’s S1P1 Polyclonal Antibody (protein A-purified) can be used for western blot applications. The antibody recognizes S1P1 at 42 kDa from human, mouse, porcine, and rat samples.

• Artikelnummer: CAY20208-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 20208-500
• Green Labware: Nein
• Verpackungseinheit: 1 ea (500 µl)
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Polyclonal
• Methode: Western Blotting
• Wirt: Rabbit