SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody (CR3022-RB)

Clone Name: CR3022-RB

Light Chain: Kappa

Product Description: This antibody binds to both SARS-CoV and SARS-CoV-2 with high affinity (PMID: 16796401 & 32065055). The initial characterization of the binding of this antibody was performed by ELISA and indicates potential for the development of diagnostic assays, as both virus-capture assays, or as controls in serological assays measuring immune responses to virus exposure. The original human IgG1 version of the antibody works synergistically in combination with another non-competing SARS antibody CR3014 and is a potential candidate for passive immune prophylaxis of SARS-CoV infection (ter Meulen et al., 2006). The original antibody (human IgG1) was also reported to bind the 2019-nCoV RBD (KD of 6.3 nM). This antibody may have potential as a therapeutic agent, alone or in combination with other neutralizing antibodies for treatment of 2019-nCoV infections (Tian et al., 2020).

Specificity/Sensitivity: This antibody binds the amino acids 318-510 in the S1 domain of the SARS-CoV Spike protein as well as SARS-CoV-2 (COVID-19) Spike protein. The antibody also binds to P462L-substituted S318–510 fragments of the SARS spike protein. The binding epitope is only accessible in the "open" confromation of the spike protein (Joyce et al. 2020)

Form: Liquid

Buffer (with preservative): PBS, 0.02% ProClin 300.

Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)

Uniprot ID: P59594

Antigen Species: SARS Coronavirus

Immunogen: The original monoclonal antibody was generated by sequencing peripheral blood lymphocytes of a patient exposed to the SARS-CoV.

Purification: Protein A purified

Conjugation: Unconjugated

Full Name: E2 glycoprotein precursor

• Artikelnummer: GTX01556-100
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX01556-100
• Green Labware: Nein
• Verpackungseinheit: 100 μg
• Mengeneinheit: STK
• Reaktivität: Virus
• Klonalität: Recombinant
• Methode: ELISA, Neutralization, Inhibition Assay
• Isotyp: IgG
• Human Gene ID: 1489668
• Wirt: Rabbit