Formulation: A crystalline solid
Formal Name: 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Purity: ≥98%
Formula Markup: C19H12Cl2N2O2
Formula Weight: 371,2
Shelf life (days): 1460
CAS Number: 280744-09-4
Notes: Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli including insulin, growth factors, cell specification factors, and cell adhesion. SB-216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3α with an IC50 value of 34 nM (similar potency for GSK3β).{15623} It stimulates glycogen synthesis in Chang human liver cells with an EC50 value of 3.6 µM and induces expression of a β-catenin-LEF/Tcf regulated reporter gene in HEK293 cells.{15623} SB-216763 protects primary neurons from death induced by the PI3-kinase pathway.{15622}
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