Product Type: Activator
CAS No.: 305834-79-1
MolecularFormula: C17H17ClN2O5
Molecular Weight: 364,8
Source: Synthetic
Purity: 98% (TLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (100mg/mL); or ethanol (40mg/mL, warm)
Appearance: White solid
Scientific Background: SC 79 is an activator of Akt (protein kinase B). Specifically, it has been shown to bind the plecktrin homology (PH) domain of Akt. This mimics the binding of Phosphatidylinositol (3,4,5)-trisphosphates, which induces a conformational change in Akt, that enhances phosphorylation and activation.
References: 1. Jo H., et al. (2012) Pro. Nat. Acad. Sci. USA. 109(26): 10581–10586.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.