Scavenger Receptor B2/CD36 Polyclonal Antibody

Formulation: 500 µl of peptide affinity-purified polyclonal antibody.

Immunogen: Synthetic peptide from an internal region of human CD36

Shelf life (days): 1095

Notes: CD36, also known as scavenger receptor B2 or fatty acid translocase, is a transmembrane glycoprotein that has roles in fatty acid uptake and lipid metabolism and signaling.{62494} It is composed of N- and C-terminal cytoplasmic tails, two transmembrane domains, and an extracellular loop that binds to a variety of lipid ligands, including long-chain fatty acids, oxidized LDL, and oxidized phospholipids, and protein ligands, such as thrombospondin (TSP-1), and is subject to post-translational modifications.{62494,62495,62496} CD36 is expressed by a variety of cells, including hematopoietic cells such as platelets, monocytes, and macrophages, as well as adipocytes, enterocytes, cardiac and skeletal myocytes, and endothelial and epithelial cells.{62494,62497} It also exists as a soluble form, sCD36, which is produced via plasma proteases.{62495} CD36 expression is regulated by several transcription factors, including peroxisome proliferator-activated receptor (PPAR), STAT3, and hypoxia-inducible factor-1α (HIF-1α), in a tissue-dependent manner.{62496,62494} It is localized to the plasma membrane and within endosomes, the endoplasmic reticulum, and mitochondria, and is translocated between these compartments in response to various stimuli, including insulin-induced PI3K signaling and muscle contraction-induced AMPK signaling, to regulate fatty acid uptake.{62495,62496} It has additional roles in the phagocytosis of apoptotic cells and P. falciparum-infected red blood cells (RBCs), angiogenesis, thrombosis, inflammation, and atherosclerosis, as well as cancer metastasis.{62498,62496} Cayman's Scavenger Receptor B2/CD36 Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. As a result of glycosylation, the antibody recognizes CD36 at approximately 88 kDa from human, mouse, and rat samples.

• Artikelnummer: CAY100011-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 100011-500
• Green Labware: Nein
• Verpackungseinheit: 1 ea (500 µl)
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Polyclonal
• Methode: Western Blotting, Immunohistochemistry
• Wirt: Rabbit