SENP6 Core Domain, His-tag Recombinant

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Applications: This enzyme is active in the SUMO3-CHOP assay.

Background: SENP6 is a SUMO/sentrin specific protease that functions to remove SUMO from conjugated proteins. SENP6 has been shown to deSUMOylate a member of the ligand-activated transcription factores called retinoid X receptor alpha. The transcriptional activity of RXRalpha is regulated by SUMOylation. Researchers have demonstrated that SENP6 has a preference for SUMO2/3 conjugates over SUMO1 conjugates.

Description: Human SENP6 Core Domain recombinant protein, with His-tag, expressed in E. coli.

Format: Aqueous buffer solution

Storage Stability: Store at or below -80°C. Stable as supplied for up to 1 year when stored dessicated at -80°C.

Tags: His-tag

Uniprot: Q9GZR1

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: 1. Choi, S.J. et al. Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1. J. Biol. Chem. 2006. 281(41):30669-77.
2. Mukhopadhyay D. et al. SUSP1 antagonizes formation of highly SUMO2/3-conjugated species. J. Cell Biol. 2006 Sep 25;174(7):939-49.

• Artikelnummer: BPS81097
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 81097
• Green Labware: Nein
• Verpackungseinheit: 25 µg
• Mengeneinheit: STK