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sFas Receptor, human recombinant (rHuFAS)
sFas Receptor, human recombinant (rHuFAS)
Artikelnummer
BOL97567.5
Verpackungseinheit
5 µg
Hersteller
Biomol
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Kategorie: Proteins
Formulation: lyophilized
Storage: -20°C
Weight: 17600 D
Purity: >95%
Description: Human recombinant sFas Receptor produced in E.coli is a single, non-glycosylated polypeptide chain containing 157 amino acids and having a molecular mass of 17.6kDa. Fas and Fas Ligand (FasL) are members of the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas initiates apoptosis in Fas-bearing cells. The apoptosis mechanism involves the recruitment of pro-caspase 8 through an adaptor molecule named FADD followed by processing of the pro-enzyme to active forms. These active caspases subsequently cleave a variety of cellular substrates leading to the eventual cell death. sFasR is able to inhibit FasL-induced apoptosis by acting as a decoy receptor whicht serves as a sink for FasL. The full length Fas Receptor is a 319 amino acids type I transmembrane protein, which contains a 157 amino acids extracellular domain, a 17 amino aicds transmembrane domain, and 145 amino acids cytoplasmic domain. The mature human Fas ECD shares 55%, 58%, a.a sequence identity with the mouse, rat, Fas, respectively.
Formulation: lyophilized
Storage: -20°C
Weight: 17600 D
Purity: >95%
Description: Human recombinant sFas Receptor produced in E.coli is a single, non-glycosylated polypeptide chain containing 157 amino acids and having a molecular mass of 17.6kDa. Fas and Fas Ligand (FasL) are members of the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas initiates apoptosis in Fas-bearing cells. The apoptosis mechanism involves the recruitment of pro-caspase 8 through an adaptor molecule named FADD followed by processing of the pro-enzyme to active forms. These active caspases subsequently cleave a variety of cellular substrates leading to the eventual cell death. sFasR is able to inhibit FasL-induced apoptosis by acting as a decoy receptor whicht serves as a sink for FasL. The full length Fas Receptor is a 319 amino acids type I transmembrane protein, which contains a 157 amino acids extracellular domain, a 17 amino aicds transmembrane domain, and 145 amino acids cytoplasmic domain. The mature human Fas ECD shares 55%, 58%, a.a sequence identity with the mouse, rat, Fas, respectively.
| Artikelnummer | BOL97567.5 |
|---|---|
| Hersteller | Biomol |
| Hersteller Artikelnummer | 97567.5 |
| Green Labware | Nein |
| Verpackungseinheit | 5 µg |
| Mengeneinheit | STK |
| Reaktivität | Human |
| Human Gene ID | 355 |
| Wirt | Escherichia Coli |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
