sFas Receptor, human recombinant (rHuFAS)

sFas Receptor, human recombinant (rHuFAS)
Artikelnummer
BOL97567.20
Verpackungseinheit
20 µg
Hersteller
Biomol

Verfügbarkeit: wird geladen...
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Kategorie: Proteins

Formulation: lyophilized

Storage: -20°C

Weight: 17.6 kD

Purity: >95%

Description: Human recombinant sFas Receptor produced in E.coli is a single, non-glycosylated polypeptide chain containing 157 amino acids and having a molecular mass of 17.6kDa. Fas and Fas Ligand (FasL) are members of the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas initiates apoptosis in Fas-bearing cells. The apoptosis mechanism involves the recruitment of pro-caspase 8 through an adaptor molecule named FADD followed by processing of the pro-enzyme to active forms. These active caspases subsequently cleave a variety of cellular substrates leading to the eventual cell death. sFasR is able to inhibit FasL-induced apoptosis by acting as a decoy receptor whicht serves as a sink for FasL. The full length Fas Receptor is a 319 amino acids type I transmembrane protein, which contains a 157 amino acids extracellular domain, a 17 amino aicds transmembrane domain, and 145 amino acids cytoplasmic domain. The mature human Fas ECD shares 55%, 58%, a.a sequence identity with the mouse, rat, Fas, respectively.
Mehr Informationen
Artikelnummer BOL97567.20
Hersteller Biomol
Hersteller Artikelnummer 97567.20
Green Labware Nein
Verpackungseinheit 20 µg
Mengeneinheit STK
Reaktivität Human
Human Gene ID 355
Wirt Escherichia Coli
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