SH5-07, CAS 1456632-41-9

Formulation: A solid

Formal Name: 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-N-hydroxy-benzamide

Purity: ≥95%

Formula Markup: C29H28F5N3O5S

Formula Weight: 625,6

Shelf life (days): 1460

CAS Number: 1456632-41-9

Notes: SH5-07 is a STAT3 inhibitor (Ki = 10.46 µM).{68426} It is selective for STAT3 over STAT1 (Ki = >100 µM). SH5-07 prevents constitutively active STAT3 DNA binding in NIH3T3 fibroblast nuclear extracts (IC50 = 3.9 µM).{47057} It is cytotoxic to AR230 and imatinib-resistant AR230 chronic myeloid leukemia (CML) cells (IC50s = 8.1 and 7 µM, respectively) and a variety of glioblastoma cancer stem cells (CSCs; IC50s = 0.195-1.12 µM).{68427,68426} SH5-07 reduces tumor growth in MDA-MB-231 breast cancer and U-251MG glioblastoma mouse xenograft models when administered at doses of 3 and 5 mg/kg, respectively.{47057} It is also active against T. gondii when used at a concentration of 5 µM.{68428}

• Artikelnummer: CAY36818-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36818-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe