Sheep anti-Cytochrome C

Sheep anti-Cytochrome C, Polyclonal, Clone: Polyclonal

Clone: Polyclonal.

Background: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.

Positive Control: Rat1 cell line; Mitochondrion matrix.

Immunogen: Full length recombinant Cytochrome.

Purification Method: Whole Antiserum, no purification.

UniProt: P00011 (Canine), P00008 (Rabbit), P62898 (Rat), P99999 (Human).

• Artikelnummer: EXAA195P
• Hersteller: Exalpha Biologicals Inc
• Hersteller Artikelnummer: A195P
• Green Labware: Nein
• Verpackungseinheit: 200 µl
• Mengeneinheit: STK
• Reaktivität: Human, Rat (Rattus), Rabbit, Dog (Canine)
• Klonalität: Polyclonal
• Methode: Immunoprecipitation, Western Blotting, Immunohistochemistry
• Wirt: Sheep