Sheep anti Human KSHV/HHV8 (cyclin)

Sheep anti Human KSHV/HHV8 (cyclin), Polyclonal, IgG

Background: Human herpervirus-8 (HHV-8) cyclin is a component of the HHV-8 virus particle. HHV8 has been found to be associated with three different diseases observed in AIDS patients; kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. To date there is much evidence to support a direct role for HHV8 in kaposi's sarcoma.

Immunogen: Inclusion Bodies from E. Coli expressing his-tagged full length human cyclin G2 protein.

Purification Method: Ammonium Sulfate Precipitation.

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.

References: Carbone, A., et al. 'Proliferation in HHV-8-positive primary effusion lymphomas is associated with expression of HHV-8 cyclin but independent of p27(kip1).' Am. J. Pathol. 2000, 156, 1209-1215

Product Specific References:

1. Godfrey, A., et al. 'Inhibiting primary effusion lymphoma by leniviral vectors encoding short hairpin RNA.' Blood, 2005, 105, 2510-2518.

2. Sugaya, M., et al. 'Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter.' Blood, 2005, 105, 2356-2363.

3. Jarviluoma, A., et al. 'KSHV viral cyclin binds to p27KIP1 in primary effusion lymphomas.' Blood, 2004, 104, 3349-3354.

UniProt: O40946 (KSHV).

Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

• Artikelnummer: EXAF105P
• Hersteller: Exalpha Biologicals Inc
• Hersteller Artikelnummer: F105P
• Green Labware: Nein
• Verpackungseinheit: 250 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Polyclonal
• Methode: Immunofluorescence, Immunohistochemistry (frozen), ELISA, Immunocytochemistry, Immunofluorescence (indirect)
• Isotyp: IgG
• Wirt: Sheep