Sheep anti Mouse 3BP2 (SH3 Binding Protein 2)

Sheep anti Mouse 3BP2 (SH3 Binding Protein 2), Polyclonal, IgG

Background: 3BP2 (SH3 binding protein 2) was identified as a protein binding to the SH3 domain of the Abl proto-oncogene. Murine 3BP2 cDNA encodes a 559 amino acid protein of 85 kDa consisting of an N-terminal PH domain, a C-terminal SH2 domain and intervening proline-rich sequences. 3BP2 interacts via its Sh2 domain with Syk family protein tyrosine kinases Syk, Zap70, Grb2, Cbl, PLC 1 and LAT in T lymphocytes and contributes to the transcriptional activation of NF-AT and AP-1. Mouse 3BP2 is 66% homologous to the human protein at the amino acid level.

Positive Control: Recombinant 3BP2 protein.

Immunogen: Antibody developed using SH2 domain of the 3BP2 protein fused to GST.

Purification Method: Ammonium Sulfate Precipitation.

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.

References: 1. Decker, M., et al. Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation. Immunity 1998, 9, 595-605

2. Songyang, Z., et al. Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk and Vav. Mol. Cell Biol. 1994, 14, 2777-2785.

UniProt: Q06649.

Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

• Artikelnummer: EXAX1090P
• Hersteller: Exalpha Biologicals Inc
• Hersteller Artikelnummer: X1090P
• Green Labware: Nein
• Verpackungseinheit: 250 µg
• Mengeneinheit: STK
• Reaktivität: Mouse (Murine)
• Klonalität: Polyclonal
• Methode: Western Blotting
• Isotyp: IgG
• Wirt: Sheep