Shield-1, CAS 914805-33-7

Formulation: A solid

Formal Name: 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2S)-2-piperidinecarboxylic acid, (1R)-3-(3,4-dimethoxyphenyl)-1-[3-[2-(4-morpholinyl)ethoxy]phenyl]propyl ester

Purity: ≥98%

Formula Markup: C42H56N2O10

Formula Weight: 748,9

Shelf life (days): 1460

CAS Number: 914805-33-7

Notes: Shield-1 is a protein stabilizing ligand that prevents the proteosomal degradation of proteins fused to FK-506 binding protein 1A (FKBP12) containing a leucine-to-proline substitution at position 106 (FKBP12L106P).{67495} It displays specific binding for the destabilizing domain FKBP12L106P and does not interfere with other measured cell processes. Shield-1 inhibits decreases in fluorescence in NIH3T3 cells stably expressing YFP-FKBP12L106P in a concentration-dependent manner. It increases secretion of IL-2-FKBP12L106P in HCT116 cells stably expressing IL-2-FKBP12L106P when used at a concentration of 1 µM.{67496} In vivo, shield-1 (5 and 10 mg/kg every two days) reduces tumor volume in a mouse xenograft model using HCT116 cells stably expressing IL-2-FKBP12L106P.

• Artikelnummer: CAY37325-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37325-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK