Product Type: Inhibitor
CAS No.: 410536-97-9
MolecularFormula: C26H22N2O2
Molecular Weight: 394,47
Source: Synthetic
Purity: >98%
Solubility: Soluble to 100 mM in DMSO
Appearance: Off-white to yellow crystals
PubChem CID: 5717148
Scientific Background: Cell-permeable, selective sirtuin deacetylase inhibitor (IC50 values are 38, 68 and 131 µM at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro.
References: 1. Grozinger CM., et al (2001) J.Biol.Chem. 276: 38837. 2. Mai A., et al (2005) J.Med.Chem. 48: 7789. 3. Kahyo T., et al (2008) J.Pharmacol.Sci. 108: 364.4. Jung-Hynes B., et al (2009) J.Biol.Chem. 284: 3823.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.