Product Description: Sivelestat (EI546) sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19[1][2][3][4].
Applications: Cancer-Kinase/protease
Formula: C20H29N2NaO11S
Citations: Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121./Oxid Med Cell Longev. 2019 Nov 23;2019:7323986./Biofabrication. 2021 Feb 1./Brain Behav Immun. 2024 Jun 12:120:403-412./Burns Trauma. 17 September 2021./Cancers (Basel). 2022, 14(3), 515./Cell Biosci. 2022 Jul 22;12(1):114./Ecotoxicol Environ Saf. 2023 Nov 18:268:115694./Elife. 2022 Mar 23:11:e77444./Exp Mol Med. 2024 Dec 2./FASEB J. 2024 Dec 15;38(23):e70238./Heliyon. 2024 Oct 5;10(19):e38895./J Cell Mol Med. 2022 Feb 11./J Exp Med. 2023 Sep 4;220(9):e20221751./J Infect Dis. 2023 Nov 28:jiad526./Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121./Res Sq. 2024 Jul 30./Research Square Preprint. 2021 Aug./Research Square Preprint. 2021 Jun./Research Square Preprint. 2023 Dec 11./J Hepatocell Carcinoma. 2021 May 20;8:451-465./Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.
References: [1]Kawabata K, et al. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun. 1991 Jun 14;177(2):814-20./[2]Yuichiro Toda, et al. A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats. Int J Mol Med. 2007 Feb;19(2):237-43./[3]Tomoharu Kono, et al. Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder. Mol Cell Biochem. 2008 Apr;311(1-2):87-92./[4]Adeleh Sahebnasagh, et al. Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19. J Clin Pharm Ther. 2020 Aug 28.
CAS Number: 201677-61-4
Molecular Weight: 528.51
Compound Purity: 99.90
Research Area: Cancer
Solubility: DMSO : 250 mg/mL (ultrasonic)
Target: Elastase;SARS-CoV
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