SN-38-d3, CAS 718612-49-8

Formulation: A solid

Formal Name: 4-ethyl-11-(ethyl-2,2,2-d3)-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Purity: ≥99% deuterated forms (d1-d3)

Formula Markup: C22H17D3N2O5

Formula Weight: 395,4

Shelf life (days): 1460

CAS Number: 718612-49-8

Notes: SN-38-d3 is intended for use as an internal standard for the quantification of SN-38 (Item No. 15632) by GC- or LC-MS. SN-38 is an inhibitor of topoisomerase I and an active metabolite of the prodrug irinotecan (Item No. 14180).{22662,51556} It is formed from irinotecan by carboxylesterases.{22662} SN-38 (0.1, 1, and 10 µM) induces topoisomerase I-dependent DNA cleavage in a cell-free assay.{51556} It induces DNA single-strand breaks in HT-29 colorectal adenocarcinoma cells when used at a concentration of 200 nM and cytotoxicity in HT-29 cells (IC50 = 8.8 nM). SN-38 (100 mg/kg per day) reduces tumor volume without affecting body weight in an MX-1 breast cancer mouse xenograft model.{51555}

• Artikelnummer: CAY40133-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 40133-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung