Sobetirome, CAS 211110-63-3

Product Description: Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC50 of 0.16 μM[1].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C20H24O4

References: [1]Gierach I, et al. Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors α-1 and β-1. FEBS Open Bio. 2012 Aug 15;2:247-53./[2]Johansson L, et al. Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10297-302./[3]Villicev CM, et al. Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats. J Endocrinol. 2007 Apr;193(1):21-9.

CAS Number: 211110-63-3

Molecular Weight: 328.40

Compound Purity: 99.91

Research Area: Metabolic Disease; Endocrinology

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Thyroid Hormone Receptor

• Artikelnummer: MEXHY-14823-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-14823-10.1
• Verpackungseinheit: 10mM/1mL
• Mengeneinheit: STK