Sodium Iodide Symporter Antibody, Clone FP5: HRP

Mouse Anti-Human Sodium-Iodide Symporter Monoclonal IgG1 Kappa

Target: Sodium Iodide Symporter

Conjugate: HRP

Product Type: Monoclonal

Clone Number: FP5

Immunogen: Mannose binding protein and human NIS fusion (AA468-643)

Swiss-Prot: Q92911

Purification: Protein G Purified

Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Detects ~97kDa, non-glycosylated version at 68kDa. Other minor bands associated with hNIS at 160kDa, and degradation products at ~30 kDa, and ~15kDa.

Cellular Localization: Membrane

Scientific Background: The sodium iodide symporter (NIS) is an ion pump that actively transports iodide across the basolateral membrane into thyroid epithelial cells (1, 2). This is important step in the process of iodide organificaton and the formation of triiodothyronine and thyroxine (3).

References: 1. Dai G., Levy O., Carrasco N. (1996) Nature. 379(6564): 458-460.2. Snabik P.A., et al. (1997) Endocrin. 138(8): 3555-3558.3. Dohan O., et al. (2007) Proc Natl Acad Sci USA. 104(51): 20250-20255.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-391D-HRP
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-391D-HRP
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Western Blotting, Immunohistochemistry, Immunocytochemistry
• Isotyp: IgG1 kappa
• Human Gene ID: 6528
• Wirt: Mouse