Spike Neutralizing Antibody (Clone LxC1-G10) (SARS-CoV-2)

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Applications: The human monoclonal neutralizing IgG can be used for functional assays to block SARS-CoV-2 Spike protein and ACE2 binding.

Assay Conditions: See protocol for detailed assay conditions

Clone Number: Clone LxC1-G10)

Description: This human monoclonal antibody recognizes SARS-CoV-2 full-length spike proteins in the native trimeric conformation. This antibody cross-reacts with the wildtype (BPS Bioscience #100728) as well as the Alpha B.1.1.7 (BPS Bioscience #510334), Beta B.1.351 (BPS Bioscience #510333), Beta B.1.351Δ242-244 (BPS Bioscience #101091), Gamma P.1 (BPS Bioscience #100989), Delta B.1.617.2 (BPS Bioscience #101147) and Delta Plus B.1.617.2.1 (BPS Bioscience #101165) variant spike trimers [Table of variants]. The human ACE2 receptor is found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. ACE2 is known to mediate COVID-19 infection through direct binding of the SARS-CoV-2 Spike protein. This neutralizing antibody has been functionally tested using BPS Bioscience Spike Trimer: ACE2 Inhibitor Screening Kits (available for purchase).

Format: Aqueous buffer solution.

Formulation: 1X PBS, 0.2% BSA

Purification: Protein A

Storage Stability: -20°C.  Stable for at least 6 months from date of receipt. 

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

• Artikelnummer: BPS101246
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 101246
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Klonalität: Monoclonal
• Isotyp: Human IgG1