STING Agonist D61, CAS 2850251-27-1

Formulation: A solid

Formal Name: 2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1-[3-fluoromethyl)phenyl]-2-oxazolyl]amino]propyl]

Purity: ≥95%

Formula Markup: C29H29F3N8O4

Formula Weight: 610,6

Shelf life (days): 730

CAS Number: 2850251-27-1

Notes: STING agonist D61 (D61) is an agonist of stimulator of interferon genes (STING).{69513} It induces expression of an IFN3-inducible secreted alkaline phosphatase (SEAP) reporter gene and an IFN-β-inducible reporter gene in cell-based assays (EC50s = 52.9 and 116 nM, respectively). D61 (4, 6, and 8 µM) increases the expression of mRNA encoding IFN-β and chemokine (C-X-C motif) ligand 10 (CXCL10) and phosphorylation of TANK-binding kinase 1 (TBK1), IRF3, and STING in THP-1 monocytes. In vivo, D61 (0.25 mg/kg every other day) reduces tumor volume without affecting body weight in a CT26 murine colon cancer model.

• Artikelnummer: CAY38706-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38706-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK