Product Type: Inhibitor
CAS No.: 594839-88-0
MolecularFormula: C14H7Cl2NO3
Molecular Weight: 308,1
Source: Synthetic
Purity: >98% (TLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (25 mg/ml, warm)
Appearance: Off-white powder
PubChem CID: 11001318
Scientific Background: Tafamidis functions as a chaperone that stabilizes the correctly folded tetrameric form of the transthyretin (TTR) protein by binding in one of the two thyroxine-binding sites of the tetramer (1). In drug form, it is used to delay impairment of peripheral nerve function in adults with familial amyloid polyneuropathy.
References: 1. Said G, Grippon S, Kirkpatrick P. (2012). Nature Reviews. Drug Discovery. 11(3): 185–186.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.