Conjugation: HRP: Horseradish Peroxidase
Description of Target: TCF7L1 participates in the Wnt signaling pathway. It binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. It is necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. TCF7L1 down-regulates NQO1, leading to increased mitomycin c resistance.
Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TCF7L1
Key Reference: Hillier,L.W., (2005) Nature 434 (7034), 724-731
Molecular Weight: 63kDa
Peptide Sequence: Synthetic peptide located within the following region:
ESENQSSSSDSEAERRPQPVRDTFQKPRDYFAEVRRPQDSAFFKGPPYPGProduct Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Protein Name: Transcription factor 7-like 1
Protein Size: 588
Purification: Affinity Purified