TDI-10229, CAS 2810887-45-5

Formulation: A solid

Formal Name: 4-chloro-6-[1,5-dimethyl-4-(phenylmethyl)-1H-pyrazol-3-yl]-2-pyrimidinamine

Purity: ≥98%

Formula Markup: C16H16ClN5

Formula Weight: 313,8

Shelf life (days): 1460

CAS Number: 2810887-45-5

Notes: TDI-10229 is an inhibitor of soluble adenylyl cyclase (sAC; IC50 = 0.2 µM for the human enzyme in a cell-free assay).{51273} It is selective for sAC over the transmembrane ACs AC1-3, -5, -8, and -9 at 10 µM. TDI-10229 inhibits cAMP accumulation induced by the phosphodiesterase (PDE) inhibitor IBMX (Item No. 13347) in rodent sAC-expressing HEK293 cells (IC50 = 0.1 µM). It also inhibits capacitation-induced cAMP accumulation and protein kinase A (PKA) activation in isolated mouse and human sperm when used at a concentration of 5 µM. TDI-10229 (5 and 50 µM) prevents the acrosome reaction and fertilization of mouse sperm with mouse oocytes in vitro.

• Artikelnummer: CAY37674-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37674-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe