Tegatrabetan, CAS 1227637-23-1

Formulation: A solid

Formal Name: rel-2,7-bis[[(3R,5S)-3,5-dimethyl-1-piperidinyl]sulfonyl]-9,10-anthracenedione 9,10-dioxime

Purity: ≥98%

Formula Markup: C28H36N4O6S2

Formula Weight: 588,7

Shelf life (days): 1460

CAS Number: 1227637-23-1

Notes: Tegatrabetan is an inhibitor of Wnt/β-catenin signaling.{67484} It reduces Wnt3a-induced transcriptional activity in a reporter activity assay using STF3a cells, which exhibit constitutive Wnt activation, when used at a concentration of 1 µM. Tegatrabetan inhibits proliferation of, and transcription in, HT-29 human colon cancer cells (IC50s = 9 and 63 nM, respectively) and reduces survival in six other cancer cell lines (IC50s = 14-80 nM). It induces cell cycle arrest at the G1 phase in HCT-15 human colon cancer cells when used at a concentration of 625 nM. In vivo, tegatrabetan (50 mg/kg per day) reduces tumor volume and inhibits lung metastasis in a Saos-2 osteosarcoma mouse xenograft model.{67485}

• Artikelnummer: CAY37423-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37423-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK