Teprenone, CAS 6809-52-5

HSP70 Inducer

Product Type: Inducer

CAS No.: 6809-52-5

MolecularFormula: C23H38O

Molecular Weight: 330,6

Source: Synthetic

Purity: >95% (GC)

Solubility: Soluble in DMSO (30 mg/ml)

Appearance: Colorless Oil

PubChem CID: 5282199

Scientific Background: Teprenone can induce expression of HSP70, HSPB8, and HSPB1. Induction of HSP70 expression is protective against the development of various diseases, such as inflammatory bowel disease, hypoxic/ischemic brain injury and spinal and bulbar muscular atrophy (cytoprotective and anti-inflammatory effects) (1, 2). Reports indicate that Teprenone protects against NSAID-induced gastric and intestinal lesions by induction of HSP70 expression (2). Other studies have shown that it induces expression of HSPB8 and HSPB1 and reduces the formation of amyloid oligomers as well as insoluble aggregates in HSPB5 R120G TG mice (3, 4).

References: 1. Kobayashi T., Ohta Y., Yoshino J and Nakazawa S. (2001) Pharmacol Res. 43(1): 23-30.2. Sambroski P., Grzymislawski M. (2015) Adv Clin Med. 24(3): 525-530.3. Marunouchi T., Inomata S., Sanbe A., Takagi N., Tanonaka K. (2014) Eur J Pharmacol. 730: 1401-47.4. Sanbe A., et al. (2009) PLoS One. 4(4): e5351.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-526-10MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-526-10MG
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK