Product Type: Antagonist
CAS No.: 63074-08-8
MolecularFormula: C19H25N5O4·HCl
Molecular Weight: 423,89
Source: Synthetic
Purity: >98%
Solubility: Soluble to 20mg/ml in warm water
Appearance: White to off-white solid
PubChem CID: 44383
Scientific Background: Terazosin (TZ) which is marketed as an alpha1-adrenergic receptor antagonist, has been shown to alleviate organ damaged and increase survival in rodent models of sepsis and stroke in vivo (1). It inhibits apoptosis in macrophages by activation of Pgk1 and Hsp90 (1).
References: 1. Chen X., et al. (2015) Nature Chem Biol. 11:19-25.2. Hancock A.A., et al. (1995) J Recept Signal Transduct Res. 15: 863.3. Kyncl J.J. (1986) Am J Med. 80:12.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.