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TFEB Polyclonal Antibody, Rabbit
TFEB Polyclonal Antibody, Rabbit
Artikelnummer
ELSE-AB-93321-60
Verpackungseinheit
60 µl
Hersteller
Elabscience Biotechnology
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Abbreviation: TFEB
Target Synonym: TFEB;ALPHATFEB;BHLHE35;TCFEB
Conjugation: Unconjugated
UNIProt ID: P34897
Background: Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response. Specifically recognizes and binds E-box sequences (5'-CANNTG-3'; efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation. Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human TFEB
Dilution: WB 1:500-1:2000,IHC 1:50-1:200,IF 1:50-1:200
Target Synonym: TFEB;ALPHATFEB;BHLHE35;TCFEB
Conjugation: Unconjugated
UNIProt ID: P34897
Background: Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response. Specifically recognizes and binds E-box sequences (5'-CANNTG-3'; efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation. Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human TFEB
Dilution: WB 1:500-1:2000,IHC 1:50-1:200,IF 1:50-1:200
| Artikelnummer | ELSE-AB-93321-60 |
|---|---|
| Hersteller | Elabscience Biotechnology |
| Hersteller Artikelnummer | ELA-E-AB-93321-60 |
| Green Labware | Nein |
| Verpackungseinheit | 60 µl |
| Mengeneinheit | STK |
| Reaktivität | Human, Mouse (Murine), Rat (Rattus) |
| Klonalität | Polyclonal |
| Methode | Immunofluorescence, Western Blotting, Immunohistochemistry |
| Isotyp | IgG |
| Wirt | Rabbit |
| Produktinformation (PDF) | Download |
| MSDS (PDF) | Download |
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Gernot Ensinger, M.Sc.
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