TGF-beta(1D11.16.8), 1mg/mL

Description: This MAb recognizes TGF beta 1, 2 and 3. Three TGF-betas have been identified in mammals. TGF-beta1, TGF-beta2 and TGF-beta3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF-beta requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF-beta3 protein has approximately 80% identity to the mature region of both TGF-beta1 and TGF-beta2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. TGF-beta's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Conjugate: Purified, BSA-free

Concentration: 1 mg/mL

Storage buffer: PBS, no BSA, no azide

Product Origin: Animal - Mus musculus (mouse)

Clone: 1D11.16.8

Entrez Gene ID: 7040 (beta1), 7042 (beta2) & 7043 (beta3)

Immunogen: Bovine TGF-beta2 protein

Expected AB Applications: Functional studies (published for clone)/IHC (FFPE) (published for clone)

Z-Antibody Applications: Functional studies (published)/IHC, FFPE (published)

• Artikelnummer: BTMBNUM0977-50
• Hersteller: Biotium
• Hersteller Artikelnummer: BNUM0977-50
• Green Labware: Nein
• Verpackungseinheit: 50 uL
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus), Monkey (Primate), Dog (Canine), Cow (Bovine), Hamster
• Klonalität: Monoclonal
• Methode: Immunohistochemistry, Functional Studies
• Isotyp: IgG1 kappa
• Wirt: Mouse