Thapsigargin, CAS 67526-95-8

Autophagy inhibitor

Product Type: Inhibitor

CAS No.: 67526-95-8

MolecularFormula: C34H50O12

Molecular Weight: 650,8

Source: Synthetic

Purity: >98% (TLC); NMR (Conforms)

Solubility: Soluble in DMSO (65mg/mL); or Ethanol (20mg/mL)

Appearance: Colorless wax or white solid.

PubChem CID: 446378

Scientific Background: Thapsigargin is a cell-permeable inhibitor of the sarco-endoplasmatic reticulum Ca2+-ATPase (SERCA). This inhibition causes the release of intracellular Ca2+ stores. Thapsigargin also inhibits autophagy. This is due to the induction of and an ER stress response, which causes downstream effects that include an accumulation of autophagosomes in the cytosol. These intermediate structures never mature into amphisomes and autolysosomes, and the autophagy process cannot be completed.

References: 1. Canová N.K., et al. (2007) Cell Biol Toxicol. 23(5): 337-54.2. Ganley I.G., et al. (2011) Autophagy. 7(11): 1397-9.3. Cheng Y., et al. (2013) Autophagy. 9(2): 208-19.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-399-1MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-399-1MG
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK