Tie2 Kinase Assay Kit

Products from BPS Bioscience require a minimum order value above 400€

Applications: Study enzyme kinetics and screen small molecular inhibitors for drug discovery and high throughput (HTS) applications.

Background: Tie2, also known as TEK Receptor Tyrosine Kinase (TEK), belongs to the tyrosine kinase family that mediates a signaling pathway that functions in embryonic vascular development. As a cell-surface receptor, Tie2 regulates angiogenesis, endothelial cell survival, proliferation, migration, and is required for normal heart development during embryogenesis. Tie2 has also been shown to play a critical role in maintaining the long-term population and quiescent status of hematopoietic stem cells in bone marrow. Overexpression of Tie2 in tumoral vessels as well as outside the vascular compartment has been linked to several types of cancers including leukemia, gastric tumors, breast tumors, and gliomas. Tie2 is a potential target for cancer therapy due to its expression in different tumoral compartments.

Contraindications: The final concentration of DMSO in the assay should not exceed 1%.

Description: The Tie2 Kinase Assay Kit is designed to measure Tie2 kinase activity for screening and profiling applications using ADP-Glo® as a detection reagent. 

Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.

Supplied As: The assay kit comes in a convenient 96-well format, with enough purified recombinant Tie2 kinase, kinase substrate, ATP and kinase assay buffer for 100 enzyme reactions.

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

• Artikelnummer: BPS78573
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 78573
• Green Labware: Nein
• Verpackungseinheit: 96 rxns.
• Mengeneinheit: PAK