TIM-4 Monoclonal Antibody

Formulation: 400 µg of protein A-purified monoclonal antibody

Immunogen: Mouse peritoneal cell TIM-4

Shelf life (days): 1095

Notes: TIM-4 is a type I transmembrane protein and member of the T cell immunoglobulin and mucin domain-containing (TIM) family of immunoregulatory proteins.{21964} It is composed of an N-terminal immunoglobulin variable (IgV) domain that binds to phosphatidylserine, as well as a mucin stalk, which contains O- and N-linked glycosylation sites, a transmembrane domain, and a C-terminal cytoplasmic tail, which lacks a tyrosine phosphorylation site, unlike TIM-1 and TIM-3.{15136,21964] TIM-4 is expressed in antigen-presenting cells (APCs) such as dendritic cells and macrophages and binds to TIM-1 on activated T cells.{21967} It is mainly involved in phagocytosis of apoptotic cells via recognition of phosphatidylserine, but also plays a role in T cell proliferation and survival, viral entry, and antitumor immunity.{15136,29982,67258,67259} TIM-4 targeting antibodies prevent HIV-1 entry into host cells in vitro and enhance the efficacy of anticancer vaccines in a murine melanoma model.{67258,67259} SNPs in TIMD4 are associated with increased susceptibility of asthma in children.{21966} Cayman's TIM-4 Monoclonal Antibody can be used for flow cytometry (FC) and immunocytochemistry (ICC) applications.

• Artikelnummer: CAY10322-400
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10322-400
• Green Labware: Nein
• Verpackungseinheit: 1 ea (400 µg)
• Mengeneinheit: STK
• Reaktivität: Mouse (Murine)
• Klonalität: Monoclonal
• Methode: Flow Cytometry, Immunocytochemistry
• Wirt: Hamster