English
TNF-R1 Antibody
Rabbit Anti-Mouse TNF-R1 Polyclonal
Artikelnummer
STRSPC-170D
Verpackungseinheit
100 µg
Hersteller
Stressmarq Biosciences
Verfügbarkeit:
wird geladen...
Preis wird geladen...
Target: TNFR1
Conjugate: Unconjugated
Product Type: Polyclonal
Immunogen: Peptide corresponding to AA 20-43 of the mouse TNF-R1 sequence, identical to rat and human over those residues
Swiss-Prot: P19438
Purification: Peptide Affinity Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~55kDa. Other bands present may be the result of oligomerization, self-aggregation and/or cleavage of the TNF-R1 extracellular domain.
Cellular Localization: Cell Membrane,Golgi Apparatus,Golgi Apparatus Membrane
Scientific Background: The Tumor Necrosis Factor Receptor (TNFR) also known as Cluster of differentiation (CD120) is a protein that belongs to the (TNF)/ (TNFR) superfamily. TNF interacts with two distinct receptors TNFR1 and TNFR2. These receptors share no homology on their cytoplasmic sequences(1,3).TNFR1 also known as p55/p60 is a high affinity receptor for TNF-α. The TNFR1 has an extracellular domain with variable numbers of cysteine-rich repeats. The functional properties of TNFR1 are targets in new therapies for osteoporosis, chronic inflammatory and autoimmune diseases (1, 2). The TNF-α/TNFR1 receptor complex is responsible for the recruitment and the subsequent activation of the caspase (aspartate-specific cysteine proteases) that regulate apoptosis.
References: 1. Kontermann R.E., et al. (2008) J Immunother. 31(3):225-34.2. Hehlgans T. and Pfeffer K. (2005) Immunology. 115(1):1-20.3. Al-Lamki S., et al. (2005) The Faseb Journal. 19:1638-1645.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Conjugate: Unconjugated
Product Type: Polyclonal
Immunogen: Peptide corresponding to AA 20-43 of the mouse TNF-R1 sequence, identical to rat and human over those residues
Swiss-Prot: P19438
Purification: Peptide Affinity Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~55kDa. Other bands present may be the result of oligomerization, self-aggregation and/or cleavage of the TNF-R1 extracellular domain.
Cellular Localization: Cell Membrane,Golgi Apparatus,Golgi Apparatus Membrane
Scientific Background: The Tumor Necrosis Factor Receptor (TNFR) also known as Cluster of differentiation (CD120) is a protein that belongs to the (TNF)/ (TNFR) superfamily. TNF interacts with two distinct receptors TNFR1 and TNFR2. These receptors share no homology on their cytoplasmic sequences(1,3).TNFR1 also known as p55/p60 is a high affinity receptor for TNF-α. The TNFR1 has an extracellular domain with variable numbers of cysteine-rich repeats. The functional properties of TNFR1 are targets in new therapies for osteoporosis, chronic inflammatory and autoimmune diseases (1, 2). The TNF-α/TNFR1 receptor complex is responsible for the recruitment and the subsequent activation of the caspase (aspartate-specific cysteine proteases) that regulate apoptosis.
References: 1. Kontermann R.E., et al. (2008) J Immunother. 31(3):225-34.2. Hehlgans T. and Pfeffer K. (2005) Immunology. 115(1):1-20.3. Al-Lamki S., et al. (2005) The Faseb Journal. 19:1638-1645.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
| Artikelnummer | STRSPC-170D |
|---|---|
| Hersteller | Stressmarq Biosciences |
| Hersteller Artikelnummer | SPC-170D |
| Green Labware | Nein |
| Verpackungseinheit | 100 µg |
| Mengeneinheit | STK |
| Reaktivität | Human, Mouse (Murine), Rat (Rattus), Monkey (Primate), Rabbit, Dog (Canine), Cow (Bovine) |
| Klonalität | Polyclonal |
| Methode | Immunofluorescence, Immunoprecipitation, Western Blotting, Immunohistochemistry, Immunocytochemistry |
| Human Gene ID | 7132 |
| Wirt | Rabbit |
| Produktinformation (PDF) | Download |
| MSDS (PDF) | Download |
Verwandte Artikel
Markieren Sie die Artikel, um Sie dem Warenkorb hinzuzufügen oder
Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
