TNP-ATP (sodium salt)

Formulation: A solution in water

Formal Name: ((3a'R,4'R,6'R,6a'R)-4'-(6-amino-9H-purin-9-yl)-2,4,6-trinitro-3a',4',6',6a'-tetrahydrospiro[cyclohexane-1,2'-furo[3,4-d][1,3]dioxole]-2,5-dien-6'-yl)methyl triphosphate, tetrasodium salt

Purity: ≥95%

Formula Markup: C16H13N8O19P3 • 4Na

Formula Weight: 806,2

Shelf life (days): 730

Notes: TNP-ATP is a derivative of ATP and an antagonist of the purinergic P2Y1, P2X3, and P2X2/3 receptors (IC50s = 6, 0.9, and 7 nM, respectively, in HEK293 cells expressing the human receptors).{36447} It is selective for these receptors over the purinergic P2X2, P2X4, and P2X7 receptors (IC50s = 2, 15.2, and >30 µM, respectively, in HEK293 cells expressing the human receptors). TNP-ATP decreases acetic acid-induced calcium flux in 1321N1 cells expressing the P2X3 and P2X2/3 receptors (IC50s = 100 and 62 nM, respectively).{36448} It reduces acetic acid-induced writhing in a mouse model of visceral pain (ED50 = 6.35 µmol/kg). It displays an emission maximum of 547 nm upon excitation at 403 nm, and its relative fluorescence increases four-fold when bound to insulin-degrading enzyme (IDE) and emission shifts to 538 nm.{36449}

• Artikelnummer: CAY38492
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38492-3.6
• Verpackungseinheit: 3.6 mg
• Mengeneinheit: STK
• Methode: Reinstoffe, Fluorescence