Tocofersolan, CAS 9002-96-4

Formulation: A solid

Formal Name: α-[4-[[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-ω-hydroxy-poly(oxy-1,2-ethanediyl)

Purity: ≥80%

Formula Markup: (C2H4O)nC33H54O5

Formula Weight: 574,8

Shelf life (days): 1460

CAS Number: 9002-96-4

Notes: Tocofersolan is a nonionic surfactant and derivative of vitamin E.{62421} It has a critical micelle concentration (CMC) of 0.02 mM at room temperature. Tocofersolan inhibits P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1), substrate-induced ATPase activity in cell-free assays (IC50s = 0.4-3.25 µM).{62422} It reverses locomotor deficits induced by the polycyclic aromatic hydrocarbon benzo[a]pyrene in zebrafish larvae when used at a concentration of 1 µM.{62423} Intravenous administration of nanocrystals containing tocofersolan (50 mg/kg) and paclitaxel (Item No. 10461) reduces tumor growth in an NCI/ADR-RES ovarian cancer mouse xenograft model.{62424} Liposomes containing tocofersolan and DOTMA (Item No. 25926) and encapsulating anti-miR-21 accumulate in the liver, lung, and spleen and decrease lung fibrosis in a mouse model of pulmonary fibrosis induced by the glycopeptide antitumor antibiotic bleomycin (Item No. 13877).{64919}

• Artikelnummer: CAY34661-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34661-10
• Verpackungseinheit: 10 g
• Mengeneinheit: STK