TPMT antibody (AT2E7)

Clone Name: AT2E7

Light Chain: Kappa

Application Note: WB: 1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 28

Form: Liquid

Buffer (with preservative): PBS, 10% Glycerol, 0.02% Sodium azide.

Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)

Background: This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]

Uniprot ID: P51580

Antigen Species: Human

Immunogen: The clone AT2E7 is derived from hybridization of mouse F2 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human TPMT protein.

Purification: Protein G Purified

Conjugation: Unconjugated

Full Name: thiopurine S-methyltransferase

• Artikelnummer: GTX57582-100
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX57582-100
• Green Labware: Nein
• Verpackungseinheit: 100 μl
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Western Blotting, Immunocytochemistry
• Isotyp: IgG1
• Human Gene ID: 7172
• Wirt: Mouse