Transgelin / SM22-alpha(TAGLN/247), 1mg/mL

Transgelin / SM22-alpha(TAGLN/247), 1mg/mL
Artikelnummer
BTMBNUM0247-50
Verpackungseinheit
50 uL
Hersteller
Biotium

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Description: This MAb recognizes a 22 kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is downregulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Conjugate: Purified, BSA-free

Concentration: 1 mg/mL

Storage buffer: PBS, no BSA, no azide

Product Origin: Animal - Mus musculus (mouse)

Clone: TAGLN/247

Entrez Gene ID: 6876

Immunogen: Recombinant full-length human transgelin (TAGLN) protein.

Verified AB Applications: IHC (FFPE) (verified)

Z-Antibody Applications: IHC, FFPE (verified)
Mehr Informationen
Artikelnummer BTMBNUM0247-50
Hersteller Biotium
Hersteller Artikelnummer BNUM0247-50
Green Labware Nein
Verpackungseinheit 50 uL
Mengeneinheit STK
Reaktivität Human, Mouse (Murine), Pig (Porcine), Rabbit, Cow (Bovine)
Klonalität Monoclonal
Methode Immunohistochemistry
Isotyp IgG1 kappa
Wirt Mouse
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