TRPM7 Antibody, Clone S74: HRP

Mouse Anti-Mouse TrpM7 Monoclonal IgG1

Target: TRPM7

Conjugate: HRP

Product Type: Monoclonal

Clone Number: S74

Immunogen: Fusion protein amino acids 1817-1863 (C- terminus) of mouse TrpM7

Swiss-Prot: Q923J1

Purification: Protein G Purified

Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Detects ~220kDa in extracts of cells transiently transfected with TrpM7. No cross-reactivity against TrpM6.

Cellular Localization: Membrane

Scientific Background: TRPs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants (1, 2).

References: 1. Brauchi S., Krapivinsky G., Krapivinsky L., Clapham D.E. (2008) Proc Natl Acad Sci USA. 105(24): 8304-8308.2. Numata T, Okada Y. (2008) J Biol Chem. 283(22): 15097-15103.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-316D-HRP
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-316D-HRP
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunohistochemistry, Immunocytochemistry
• Isotyp: IgG1
• Human Gene ID: 58800
• Wirt: Mouse