Target Synonym: TTLL12; dJ526I14.2; tubulin tyrosine ligase like 12
Storage: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Background: Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3. Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunogen: Recombinant fusion protein of human TTLL12
Dilution: WB 1:500-1:2000
Calculated MW: 74kDa
Observed MW: Refer to figures
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