Tubulysin A, CAS 205304-86-5

Product Description: Tubulysin A (TubA) is an anticancer and antiangiogenic agent with anti-microtubule, anti-mitosis and anti-proliferative activity against a variety of cancer cells with IC50 values in the pmol range. It can induce apoptosis of cancer cells and has no effect on normal cells. Tubulysins are a group of potent cytotoxins consisting of nine members (A-I). Tubulysin A can synthesize ADC as ADC CytotoxinADC Cytotoxin[1][2][3][4].

Applications: Cancer-programmed cell death

Formula: C43H65N5O10S

References: [1]Kaur G, et al. Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product. Biochem J. 2006 Jun 1;396(2):235-42./[2]Sasse F, et al. Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties. J Antibiot (Tokyo). 2000 Sep;53(9):879-85./[3]Khalil MW, et al. Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria. Chembiochem. 2006 Apr;7(4):678-83./[4]Schluep T, et al. Polymeric tubulysin-peptide nanoparticles with potent antitumor activity. Clin Cancer Res. 2009 Jan 1;15(1):181-9.

CAS Number: 205304-86-5

Molecular Weight: 844.07

Compound Purity: 99.08

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: ADC Cytotoxin;Antibiotic;Microtubule/Tubulin

• Artikelnummer: MEXHY-15995-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15995-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK