UK 122 (trifluoroacetate salt), CAS 1186653-73-5

Formulation: A solid

Formal Name: 4-[(E)-(5-oxo-2-phenyl-4(5H)-oxazolylidene)methyl]-benzenecarboximidamide, 2,2,2-trifluoroacetate

Purity: ≥95%

Formula Markup: C17H13N3O2 • CF3COOH

Formula Weight: 405,3

Shelf life (days): 1095

CAS Number: 1186653-73-5

Notes: UK 122 is an inhibitor of urokinase-type plasminogen activator (uPA; IC50 = 0.2 µM).{66580} It is selective for uPA over tissue-type plasminogen activator (tPA), trypsin, plasmin, and thrombin (IC50s = >100 µM for all). UK 122 (100 µM) inhibits the migration and invasion of CFPAC-1 pancreatic cancer cells. It prevents glutamate-induced phase shifts in isolated suprachiasmatic nucleus slices from tPA-/- but not wild-type mice when used at a concentration of 0.2 µM.{66581} UK 122 (4 mg/kg) decreases disease severity and colorectal levels of RANTES in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250).{66582}

• Artikelnummer: CAY9001218-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9001218-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK