Product Description: Urea (Standard) is the analytical standard of Urea. This product is intended for research and analytical applications. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
Formula: CH4N2O
References: [1]Bennion BJ, et al. The molecular basis for the chemical denaturation of proteins by urea. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5142-7./[2]Pan M, et al. Urea: a comprehensive review of the clinical literature. Dermatol Online J. 2013 Nov 15;19(11):20392./[3]Wang H, et al. Urea. Subcell Biochem. 2014;73:7-29./[4]Michea L, et al., Cell cycle delay and apoptosis are induced by high salt and urea in renal medullary cells. Am J Physiol Renal Physiol. 2000 Feb;278(2):F209-18./[5]Zhang Z, et al., High urea and NaCl carbonylate proteins in renal cells in culture and in vivo, and high urea causes 8-oxoguanine lesions in their DNA. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9491-6. /[6]Prabhakar SS, et al., Urea inhibits inducible nitric oxide synthase in macrophage cell line. Am J Physiol. 1997 Dec;273(6):C1882-8. /[7]Yang XY, et al., ERK activation by urea in the renal inner medullary mIMCD3 cell line. Am J Physiol. 1999 Aug;277(2):F176-85./[8]Ogino Y, et al., Effects of chronic, urea-induced osmotic diuresis on kidney weight and function in rats. Diabetologia. 1994 Mar;37(3):225-31.
CAS Number: 57-13-6
Molecular Weight: 60.06
Compound Purity: 95.30
Research Area: Cardiovascular Disease; Cancer
Target: Apoptosis;Carbonic Anhydrase;Endogenous Metabolite;ERK
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