Clone Name: DRP3/20C5
Application Note: IHC-Fr: 1:2–1:10. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 394
Specificity/Sensitivity: This antibody recognizes amino terminal domain of the human homolog of human dystrophin, utrophin.
Form: Liquid
Buffer (with preservative): Tissue culture supernatant, 0.09% Sodium azide.
Concentration:
Background: This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Uniprot ID: P46939
Antigen Species: Human
Immunogen: Fusion protein containing the first 261 amino acids of the published DMDL gene sequence.
Purification: Unpurified
Conjugation: Unconjugated
Full Name: utrophin