VEGFR2 (KDR), Avi-Tag, His-Tag, Biotin-Labeled Recombinant

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Encompassing Amino Acids: 20-764

Application: Useful for the SDS-PAGE and avidin-binding assays.

Background: The interaction between VEGF (Vascular Endothelial Growth Factor) and its receptor VEGFR is an important mediator of angiogenesis as well as endothelial cell survival and proliferation. VEGFR2 is a receptor tyrosine kinase that plays a major role in cellular responses driven by VEGF. Targeting the kinase activity of VEGFR2 has been an attractive tool in cancer therapy based on its anti-angiogenesis effects. In addition to the kinase inhibitors, humanized monoclonal antibodies interfering with VEGF/VEGFR2 interaction have been developed as anti-cancer treatments.

Description: Recombinant human VEFGR2 (vascular endothelial growth factor receptor 2), also known as kinase insert domain receptor (KDR), encompassing amino acids 20-764 corresponding to the extracellular domain of the receptor. This construct contains a C-terminal Avi-Tag™ followed by an His-tag (6xHis). This protein was affinity purified. 

Format: Aqueous buffer solution.

Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol

Genbank: NM_002253.4

Host Cell Line: HEK293

Purity: ≥90%

Storage Stability: At least 6 months at -80°C.

Tags: C-terminal Avi-Tag™, His-Tag

Uniprot: P35968

Warnings: Avoid freeze/thaw cycles

Biosafety Level: Not applicable (BSL-1)

• Artikelnummer: BPS102133-1
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 102133-1
• Verpackungseinheit: 10 µg
• Mengeneinheit: STK
• Wirt: Human