VHL Polyclonal Antibody, Rabbit

Abbreviation: VHL

Target Synonym: VHL;HRCA1;RCA1;VHL1;pVHL;PVHL

Conjugation: Unconjugated

UNIProt ID: P40337

Background: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Concentration: 1mg/mL

Immunogen: A synthetic peptide of human VHL

Dilution: WB 1:500-1:2000

• Artikelnummer: ELSE-AB-93053-200
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-E-AB-93053-200
• Green Labware: Nein
• Verpackungseinheit: 200 µl
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine)
• Klonalität: Polyclonal
• Methode: Western Blotting
• Isotyp: IgG
• Wirt: Rabbit